The improvements in accident figures are being attributed to road safety campaigns and efforts to educate young drivers.
In Lincolnshire, deaths and casualties fell to 118 last year, down from 143 in 2007.
The figures were released by North Lincolnshire Road Safety Partnership, which said that it was evidence that its work to improve road safety skills and tackle drink and drug driving was paying off.
Road deaths and serious injuries have halved in the last 10 years in Cumbria, delighting road safety experts based in the region.
The figures from the county show a decline in accident figures from an average of 555 in the years 1994-1998, down to 236 in 2008.
Road safety campaigns in Cumbria have targeted younger drivers, offering those aged 17-20 extra lessons after they have passed their tests.
Norfolk has also reported a fall in deaths and serious accidents on its roads in the past year, with around a third fewer road accidents than the previous year.
Last year in Norfolk there were 38 fatalities, a drop of 32% on the previous year, and the lowest total on record.
The chairman of the Norfolk Road Casualty Reduction Group, John Joyce, said, "The figures for fatalities have been stubbornly stable for some time, so the 2008 statistics are cause for optimism.
These figures add up to the most significant reduction in recent years, by some margin.